Repeated Commit-or-Defer Decisions with a Deadline: The Influenza Vaccine Composition

نویسندگان

  • Laura J. Kornish
  • Ralph L. Keeney
چکیده

Seasonal products have an effective inventory deadline, a time by which the inventory must be ready to distribute. The deadline creates an incentive to start early with production. However, opportunities to gather information that might change production decisions provide an incentive to defer the start of production. We study the resultant dynamic decision problem with alternatives that commit to one of several courses of action now and an alternative to defer the commitment to gather more information about the possible consequences of each alternative. The deadline increases the effective cost of gathering information because that cost includes the value sacrificed by reducing the time available to produce inventory. We frame our model using the annual influenza vaccine composition decision: deciding between strains of the virus to include, which must happen in the spring to allow time for vaccine production before the fall flu season begins. Our analysis describes the optimal decision strategies for this commit-or-defer decision. Many insights are drawn from this model that could contribute to more informed flu vaccine composition decisions. We comment on the relevance of this commit-or-defer decision model to a firm’s production decisions for other seasonal products with an inventory deadline such as fashion goods.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Deliberation with a Deadline: The Influenza Vaccine Composition Decision∗

We analyze deliberation strategies in a setting with a production deadline. In this dynamic decision problem, there is a choice between two courses of action and a third alternative of delaying the commitment to gather more information about the prevalence or popularity of each action. The deadline affects the cost of information gathering, which in this case is the value that is sacrificed by ...

متن کامل

Challenges and Perspectives toward Development of more Effective Influenza Vaccine

Influenza viruses continue to be a major health threat in human and bird populations. The improvements in formulation and production level of the current influenza vaccines are not sufficient to afford complete protection. The continuous antigenic drifts and emergence of endemic and zoonotic strains make influenza vaccine planning difficult. Concern about the emergence of new influenza pandemic...

متن کامل

Detection of Twitter Users' Attitudes about Flu Vaccine based on the Content and Sentiment Analysis of the Sent Tweets

Introduction: The influenza vaccine is one of the controversial challenges in today's societies. Considering the importance of using the flu vaccine in preventing the spread of influenza virus, the Twitter network, as a rich source of data, provides suitable conditions for research in this field to examine the attitudes of different people about this vaccine. The results in one hand will help h...

متن کامل

Detection of Twitter Users' Attitudes about Flu Vaccine based on the Content and Sentiment Analysis of the Sent Tweets

Introduction: The influenza vaccine is one of the controversial challenges in today's societies. Considering the importance of using the flu vaccine in preventing the spread of influenza virus, the Twitter network, as a rich source of data, provides suitable conditions for research in this field to examine the attitudes of different people about this vaccine. The results in one hand will help h...

متن کامل

Heamagglutinin Conserved Domain (HA2) Prepared in Prokaryotic System is Immunogenic in Mice but not Protective against Lethal Influenza Challenge

Background and Aims: Influenza vaccine production process is time-consuming with little-to-no cross-protection which requires annual adjustment. The construction of a universal vaccine to deal with the pandemics and epidemics which occasionally threat human population is the aim of many researches worldwide. Today, influenza vaccines are mostly against two major antigenic proteins, hemagglutini...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Operations Research

دوره 56  شماره 

صفحات  -

تاریخ انتشار 2008